性能参数

产品名称

PND-1186 hydrochloride

规格

10mM*1 mL in DMSO 5 mg 10 mg 50 mg 100 mg

货号

GOY-Y3022

 含量

>98.00%

CAS

1356154-94-3

别名

N/A

化学名

N/A

分子式

C25H27ClF3N5O3

分子量

分子量 537.96

溶解度

DMSO : 200 mg/mL (371.77 mM; Need ultrasonic)|H2O : 20 mg/mL (37.18 mM; Need ultrasonic)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis[1].

PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397[1]. In murine 4T1 breast carcinoma cells, FAK is important in promoting an invasive and metastatic cell phenotype. Increasing concentrations of PND-1186 (0.1 to 1.0 μM) added to 4T1 cells inhibits FAK Tyr-397 phosphorylation (pY397) and results in elevated levels of total FAK protein within 1 h[1].

PND-1186 (30 mg/kg or 100 mg/kg; subcutaneously; injected subcutaneously in the neck region) inhibits 4T1 subcutaneous tumor growth by induction of apoptosis[1].

[1]. Tanjoni I, et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther. 2010 May 15;9(10):764-77.

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噻吩 99%  碳酸锂  ACS, ≥99.0%

SF-1010手持式电磁感应铝箔封口机  封口直径Φ15-70mm  碳酸锂 SP

3-氨基酚 98%  碳酸锂 99.99% metals basis

2,6-二硝基甲苯 98%  碳酸锂 5N

2,5-二甲基苯酚 99%  氟化镧 99.99% metals basis

2,5-二甲基苯酚 分析标准品，>99.8%  氧化镧 SP

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