性能参数

产品名称

TIC10 isomer

规格

10mM (in 1mL DMSO) 10mg 20mg 50mg 100mg

货号

GOY-Y3056

 含量

>98.00%

CAS

41276-02-2

别名

ONC201 isomer

化学名

7-benzyl-10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one

分子式

C24H26N4O

分子量

分子量 386.49

溶解度

≥ 6.43mg/mL in DMSO with gentle warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

TIC10 (TRAIL-inducing compound 10) is a potent and stable small molecule that is orally active. It induces TRAIL transcriptionally independent of p53 and crosses the blood-brain barrier. [1]

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an apoptosis inducer in a variety of human cancer cell lines. It also acts as a tumor suppressor during immune surveillance but the function is lost in cancer progression. [1]

TIC10 caused a prominent and long-lasting production of TRAIL on cell surface of tumor cell.

TIC10 also led to TRAIL-mediated apoptosis in HCT116 p53-/- cells. In addition, TIC10 inactivated Akt and ERK cooperatively lead to the nuclear translocation of Foxo3a and ensuing TRAIL up-regulation. [1]

In mouse caner xenograft, TIC10 showed TRAIL-dependent antitumor effect. It caused tumor-specific cell death by RAIL-mediated direct and bystander effects. TIC10 is also an effective antitumor agent for orthotopic human glioblastoma multiforme tumors. [1]

钨酸钠 CP,99.0%  钨粉 9.95%,<1.1μm

4-甲氧基 99%  碳化钛 99%,2-4μm

酪胺 98%  碳化钛 99%,40nm

盐酸酪胺 98%  碳化钛 99.99% metals basis

2-乙?；拎?99%  氮化钛 99%，20nm

2-乙?；拎?≥99%,FG,FCC  氮化钛 99.5%,2-10 μm

Purity: >99.00%

PF-06305591 dihydrate5mg>99.00%Cas No. N/AC15H26N4O3

Picaridin-d31 mg>99.00%Cas No. N/AC12H20D3NO3

Spermine tetrahydrochloride100mg>99.00%Cas No. 306-67-2C10H26N4.4HCl

Sotalol-d6 (hydrochloride)1mg>99.00%Cas No. 1246820-85-8C12H14D6N2O3S.HCl

Trifluoperazine-d3 (hydrochloride)1 mg>99.00%Cas No. 1432064-02-2C21H21D3F3N3S.2HCl

Pyr310mg 50mg>99.00%Cas No. 1160514-60-2C16H11Cl3F3N3O3