性能参数

产品名称

Ramipril

规格

10mM (in 1mL DMSO) 50mg

货号

GOY-Y3148

 含量

>98.00%

CAS

87333-19-5

别名

化学名

(2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid

分子式

C23H32N2O5

分子量

分子量 416.51

溶解度

≥ 17.55mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.

Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM[1]. Ramipril (HOE-498) enhances the activity of ACE-associated CK2 and the phosphorylation of ACE Ser1270 in cultured endothelial cells, but is unable to activate JNK or stimulate the nuclear accumulation of c-Jun in endothelial cells expressing a S1270A ACE mutant or in ACE-deficient cells. Prolonged Ramipril treatment increases ACE expression in primary cultures of human endothelial cells and in vivo (mouse lung), which can be prevented by pretreatment with the JNK inhibitor SP600125[2].

Chronic in vivo administration of Ramipril (HOE-498) to rats at a dosage that has similar hypotensive effects in vitro HUVECs significantly reduces the rate of LPS-induced apoptosis compared to the other ACE inhibitors, which contrasts with the apoptosis effect in vitro[3]. Ramipril (HOE-498) inhibits systolic blood pressure (SBP) with IC50 of 1.97 mg/kg in spontaneously hypertensive rats (SHR). When in combination with AT1-receptor blockade by candesartan-cilexetil increases SBP reduction synergistically rather than additively[4].

K-975  分子量 287.745 mg 10 mg 25 mg 50 mg 100 mg  >98.50%  Cas No. 2563855-03-6  C16H14ClNO2

Jagged-1 (188-204) TFA  分子量 2221.421mg 5mg 10mg 50mg 100mg  >99.50%  Cas No. N/A  C95H128F3N25O28S3

IWP-O1  分子量 432.485mg 10mg 25mg 50mg 100mg  >99.00%  Cas No. 207

Benzomalvin C1mg>95.00%Cas No. 157047-98-8C24H17N3O3

Cortistatin-29 (rat) (trifluoroacetate salt)500μg>95.00%Cas No. 1815618-17-7C161H240N46O41S2?XCF3COOH

Cortistatin-29 (1-13) (rat) (trifluoroacetate salt)1mg>95.00%Cas No. N/AC68H105N23O21?XCF3COOH

Antisauvagine-30 (trifluoroacetate salt)500 μg 1 mg>95.00%Cas No. N/AC161H274N48O46S·XCF3COOH

Anthirine1 mg 5 mg>95.00%Cas No. 16049-28-8C19H24N2O