性能参数

产品名称

Sildenafil Citrate

规格

10mM (in 1mL DMSO) 25mg 50mg 500mg

货号

GOY-Y3247

 含量

>98.00%

CAS

171599-83-0

别名

化学名

5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one;2-hydroxypropane-1,2,3-tricarboxylic acid

分子式

C22H30N6O4S.C6H8O7

分子量

分子量 666.7

溶解度

≥ 25.35 mg/mL in DMSO, ≥ 2.97 mg/mL in H2O with ultrasonic and warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Sildenafil Citrate is a potent inhibitor of cGMP-specific phosphodiesterase including PDE5 with IC50 values of 3.6 nM.[1]

PDE5 (cGMP-specific phosphodiesterase type 5) is an enzyme from the phosphodiesterase class. The function of PDE5 is to accept cGMP and breaks it down. cGMP (cyclic guanosine monophosphate) is one of second messenger which is the production of guanylate cyclase. cGMP is a regulator of cellular apoptosis glycogenolysis, conductance , and ion channel. It can relaxe smooth muscle tissues. In blood vessels, It also can relaxe vascular smooth muscles, then lead to increased blood flow and vasodilation. The inhibitors of PDE5 can inhibit the degradation of cGMP, then leads to increase bloodflow to the penis. Sildenafil Citrate is used treatment of erectile dysfunction.

Sildenafil is a potent cGMP-specific phosphodiesterase. It is highly selective for PDE5. It inhibits the activity of PDE5 with an IC50 value of 3 nM in human corpus cavernosum (3.6nM in isolated rabbit platelets). At the same condition, It inhibits the activity of PDE1 and PDE3 activities with IC50s = 0.26 and 65 μM, respectively.[1] Sildenafil potently relaxed anococcygeus muscle strip swith maximum response of 100 ± 2% and a pEC50 value of 6.44 ± 0.03 in rat. Sildenafil also increased by approximately 55% the duration of nitrergic relaxations.[1, 2] Compared to the base salt, the citrate salt has pharmacokinetics and superior water solubility.[3]

4,4'-二氯苯偶酰  3457-46-3  N-叔丁氧羰基-L-天冬氨酸 1-叔丁酯  34582-32-6

3,6-二氯-4,5-二甲基哒嗪  34584-69-5  5-羟基吡嗪-2-羧酸  34604-60-9

5-溴-1-戊醇  34626-51-2  5-羟基-1-茚酮  3470-49-3

6-氨基-1,2,3,4-四氢-1-萘酮  3470-53-9  1-苄基-3-甲基-4-哌酮  34737-89-8

5-溴异喹啉  34784-04-8  6-溴异喹啉  34784-05-9

叔丁?

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