性能参数

产品名称

Sorafenib Tosylate

规格

10mM (in 1mL DMSO) 20mg 50mg 200mg

货号

GOY-Y3250

 含量

>98.00%

CAS

475207-59-1

别名

化学名

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-methylbenzenesulfonic acid

分子式

C21H16ClF3N4O3.C7H8O3S

分子量

分子量 637.03

溶解度

≥ 31.85mg/mL in DMSO, ≥ 4.15 mg/mL in EtOH with ultrasonic

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Sorafenib tosylate, also named nexavar, is a small-molecule anticancer compound [1]. It is also a novel oral Raf kinase and a vascular endothelial growth factor receptor (VEGFR) inhibitor. It inhibits tumor cell proliferation and tumor angiogenesis [2]. To HepG2 cells (1× 106), the IC50 of sorafenib tosylate is 2.09μg/ml [3].

Raf is a mitogen-stimulated protein kinase that functions as a component of the signaling cascade that leads to the stimulation of mitogen-activated protein kinase [4].

Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells [5].

Treatment with nexavar potently inhibited the cell proliferation of MV4-11 cells (FLT3-ITD) in a dose-dependent manner with an IC50 of 0.88 nM. In MV4-11 cells, sorafenib tosylate of a concentration of 100 nM induced 43.6±5.2% of the cells to undergo apoptosis whereas in EOL-1 cells a concentration as low as 10 nM induced 89.29±1.8% of the cells to be apoptotic [6].

Nude rats at the age of 6 weeks injected with 105 MDA-MB-231 cells were involved. After monotherapy with sorafenib tosylate a significant reduction of the osteolytic lesion volume was observed on days 45 and 55 and of the soft tissue component volume on day 55 in comparison to untreated animals (p < 0.05). Compared to controls, treatment with sorafenib tosylate made bone metastases show significantly decreased values of Amplitude A and kep from day 35 to 55 (Amplitude A: p<0.01; kep p<0.01 on days 35 and 55; p<0.05 on day 45) [7].

Boc-1-氨基环戊烷羧酸  35264-09-6  3-氟甲苯  352-70-5

2-(三氯乙酰)吡咯  35302-72-8  三氟化硼-二甲醚络合物  353-42-4

1-(2-甲氧苯基)哌嗪  35386-24-4  二氟溴乙酸  354-08-5

3-氨基苯甲酰胺  3544-24-9  1,1,1-三氯三氟乙烷  354-58-5

五氟碘乙烷  354-64-3  2-氨基-3,5-二溴吡啶  35486-42-1

全氟己基碘烷  355-43-1  1-叔丁基-3-碘苯  35779-0?

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