性能参数

产品名称

Tandutinib 

规格

0mM (in 1mL DMSO) 100mg 200mg 500mg

货号

GOY-Y3252

 含量

>98.00%

CAS

387867-13-2

别名

化学名

4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide

分子式

C31H42N6O4

分子量

分子量 562.72

溶解度

≥ 17.85mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Tandutinib (MLN518, CT53518) is a novel, selective and small-molecule inhibitor of FLT3 with IC50 value of 0.22μM [1].

Tandutinib (MLN518) has been reported to inhibit FLT3, PDGFR and c-Kit in in vitro kinase assays with IC50 values of 0.22μM, 0.20μM and 0.17μM, respectively. In addition, Tandutinib (MLN518) has been revealed to inhibit wild-type FLT3 or W51 tyrosine phosphorylation with an IC50 value of 30–100 nM. Furthermore, Tandutinib (MLN518) has shown the cell antiproliferation of the FLT3-ITD-positive cells （Molm-13 and Molm-14 cells） with an IC50 value of 10 nM, whereas the FLT3-ITD-negative cells ( THP-1, KG-1, and RS4 cells) were resistant, requiring 1000-fold higher concentrations to inhibit cell growth [1]

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1-溴-3,3-二甲氧基丙烷  36255-44-4  2',3'-异丙叉腺苷  362-75-4

5-乙?；?2-甲基吡啶  36357-38-7  3,4-二甲基苯乙酮  634430

环戊基甲醇  3637-61-4  2,5-二氟硝基苯  364-74-9

氮杂环丁烷盐酸盐  36520-39-5  邻三氟甲基苯肼  365-34-4

六水硝酸铥  36548-87-5  2,3-二氟氯苯  3655?

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