性能参数

产品名称

Vatalanib (PTK787) 2HCl

规格

10mM (in 1mL DMSO) 10mg 50mg 100mg

货号

GOY-Y3259

 含量

>98.00%

CAS

212141-51-0

别名

化学名

N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine;dihydrochloride

分子式

C20H15ClN4.2HCl

分子量

分子量 419.73

溶解度

≥ 21mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Vatalanib, also known as PTK787, is a potent vascular endothelial growth factor (VEGF) receptor tyrosine kinases inhibitor that inhibits VEGF receptor/KDR, VEGF receptor/Flt-1 and VEGF receptor/Flk with the half maximal inhibition concentration IC50 values of 0.037 μM, 0.077 μM and 0.27 μM respectively [1].

Vatalanib also inhibits other tyrosine kinases belonging to the same family of tyrosine kinase receptors as the VEGF receptors, including the platelet-derived growth factor receptor β tyrosine kinase (PDGFR-β), c-Kit and c-Fms, to a lesser degree with IC50 values of 0.58 μM, 0.73 μM and 1.4 μM respectively [1].

Vatalanib has been found to be potentially therapeutic for the treatment of angiogenesis-related diseases including solid tumors [1].

米诺地尔  38304-91-5  丙二酸单甲酯钾盐  38330-80-2

2-羟基嘧啶盐酸盐  38353-09-2  2-溴-4'-(三氟甲基)苯乙酮  383-53-9

二氟氯乙酯  383-62-0  2-硝基三氟甲苯  384-22-5

1,2-二氢-2-异丁氧基喹啉-1-甲酸异丁酯  38428-14-7  3-甲氧基丙酸甲酯  713201

2-巯基烟酸  38521-46-9  4-甲基-5-羟甲基咪唑盐酸盐  38585-62-5

5-羟甲基噻唑  38585-74-9  (二甲氨?

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