性能参数

产品名称

S- (+)-Rolipram

规格

10mM (in 1mL DMSO) 5mg 10mg 25mg 50mg

货号

GOY-Y3268

 含量

>98.00%

CAS

85416-73-5

别名

化学名

(4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one

分子式

C16H21NO3

分子量

分子量 275.34

溶解度

≥ 13.9 mg/mL in DMSO, ≥ 20.76 mg/mL in EtOH with ultrasonic and warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.Target: PDE4B; PDE4DRolipram, a selective inhibitor of the cyclic AMP-specific phosphodiesterase (PDE IV). Rolipram did not inhibit 5-lipoxygenase activity but did inhibit human monocyte production of leukotriene B4 (LTB4, IC50 3.5 microM). Rolipram inhibited arachidonic acid-induced inflammation in the mouse, while the low Km-cyclic-GMP PDE inhibitor. Rolipram had a modest effect on LTB4 production in the mouse, but markedly reduced LTB4-induced PMN infiltration [1]. In humans and animals rolipram produces thereby a variety of biological effects. These effects include attenuation of endogenous depression and inflammation in the central nervous system (CNS), both effects are of potential clinical relevance [2].

3,5-二甲基金刚胺盐酸盐  41100-52-1  2-氧代-4-苯丁基磷酸二甲酯  41162-19-0

叔戊氧基钾  41233-93-6  三唑钠  41253-21-8

4-甲氨基-3-硝基苯甲酸  41263-74-5  4-异丙基苯甲醚  4132-48-3

6-溴-3,4-二氢-1H-2-萘酮  4133-35-1  2,4,6-三氯苯甲酰氯  4136-95-2

邻羟基对氨基苯甲酸甲酯  4136-97-4  5-磷酸吡哆醛  41468-25-1

4-溴-2-氟联苯  41604-19?

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