性能参数

产品名称

Scriptaid

规格

10mM (in 1mL DMSO) 5mg 10mg 50mg 100mg

货号

GOY-Y3269

 含量

>98.00%

CAS

287383-59-9

别名

化学名

6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide

分子式

C18H18N2O4

分子量

分子量 326.35

溶解度

≥ 13.1 mg/mL in DMSO, ≥ 3.17 mg/mL in EtOH with ultrasonic and warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Scriptaid, identified by a high-throughput transcriptional screening, is a novel histone deacetylase (HDAC) with specific potency towards class I HDACs (50% inhibition concentration IC50 values of 0.6 μM for HDAC1 and HDAC3 and 1 μM for HDAC8). Scriptaid shares a similar chemical structure with several others hydroxamic acid-containing HDAC inhibitors (such as TSA and nullscript), which consists of a hydroxamic acid group, an aliphatic chain and an aromatic cap at the other end. Scriptaid has the potential to be used for the treatment of glioblastoma multiforme (GBM), one of the most challenging solid cancers to treat, for its ability to induce apoptosis in glioblastoma cells.

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