性能参数

产品名称

TCS-PIM-1-4a

规格

10mM (in 1mL DMSO) 5mg 10mg 50mg 100mg

货号

GOY-Y3271

 含量

>98.00%

CAS

327033-36-3

别名

化学名

5-(3-(trifluoromethyl)benzylidene)thiazolidine-2,4-dione

分子式

C11H6F3NO2S

分子量

分子量 273.23

溶解度

≥ 9.4mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

TCS-PIM-1-4a (SMI-4a) is a pan-Pim kinases inhibitor that blocks mTORC1 activity via activation of AMPK. TCS-PIM-1-4a kills a wide range of both myeloid and lymphoid cell lines (IC50 values ranging from 0.8 μM to 40 μM) [1][2].

TCS-PIM-1-4a (10 μM; 24-48 hours; 6812/2 cells and Jurkat cells) treatment increases the population of cells in the G1 phase from 44.3% to 68.4% and from 56.2% to 67.1% in 6812/2 and Jurkat, respectively. S-phase cells are decreased in 6812/2, whereas only small changes are seen in Jurkat cells consistent with the lesser G1 block[1].TCS-PIM-1-4a (5 μM; 6 hours; 6812/2 cells and Jurkat cells) induces cell death by the induction of apoptosis[1]. TCS-PIM-1-4a (5 μM; 4-8 hours; 6812/2 cells and Jurkat cells) prevents the increase in 4E-BP1 protein levels and inhibits mTOR-directed phosphorylation on Thr37/46[1].

TCS-PIM-1-4a (SMI-4a; 60 mg/kg; oral gavage; twice daily; for 21 days; nu/nu nude mice) treatment causes a significant delay in the tumor growth without any change in the weight, blood counts, or chemistries[1].

4,4-二甲基环己酮,98%  4255-62-3  6-氯尿嘧啶  4270-27-3

3-羟基金刚烷  42711-75-1  5-甲基-3-羟基吡啶  42732-49-0

2-氨基-5-溴-6-甲基吡啶  42753-71-9  2,5-噻吩二羧酸  4282-31-9

3-溴-4-氯苯甲酸  42860-10-6  6-溴正己醇  4286-55-9

3-溴-4-甲基苯甲腈  42872-74-2  2-氨基-4-甲氧基苯甲酸  4294-95-5

2,3-二氢-1H-喹啉-4-酮  4295-?

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