性能参数

产品名称

Vildagliptin

规格

10mM (in 1mL DMSO) 10mg 25mg 50mg 100mg

货号

GOY-Y3273

 含量

>98.00%

CAS

274901-16-5

别名

化学名

(2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile

分子式

C17H25N3O2

分子量

分子量 303.4

溶解度

≥ 12.05 mg/mL in DMSO, ≥ 96.4 mg/mL in EtOH with ultrasonic, ≥ 96.8 mg/mL in H2O with ultrasonic

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

LAF-237 is a potent inhibitor of DDP-4 with IC50 value of 2.3 nM [1].

DDP-4 is an antigenic enzyme expressed on the surface of most cell types and is associated with signal transduction, apoptosis and immune regulation [1].

LAF-237 is a specific inhibitor of DDP4 and can reduce glycemia. When tested on Type II diabetes patients, LAF-237 inhibits the inactivation of GLP-1 by DPP-4, allowing GLP-1 to increase the secretion of insulin and decrease glucagon release [2].

In the glucose tolerance test with obese male Zucker rats, LAF-237 can significantly decrease glucose excursion and stimulates insulin secretion. There are 95% inhibition activities of DDP-4 two hours after the injection of LAF-237[3]. Through enhances beta cell replication and reduces apoptosis, LAF-237 increases in the number of beta cell and can sustain for 12 days after washout LAF-237. Also, LAF-237 can protect nerve fiber loss in STZ-induced diabetic  male Sprague Dawley rats [4].

4-喹啉甲醛  4363-93-3  2-氯甲基吡啶  4377-33-7

2,6-二氟苯甲醚  437-82-1  4-(4-氨基苯基)吗啉-3-酮  438056-69-0

(R)-1-N-BOC-3-哌嗪甲酸甲酯  438631-77-7  2-碘氰基苯  4387-36-4

2-氨基-6-甲基苯甲酸  4389-50-8  2,3-二甲氧基苄胺  910797

4-苄氧基苯甲醛  4397-53-9  4-氨基苄胺  4403-71-8

3-呋喃甲醇  4412-91-3  2-氰甲基苯并咪唑 ?

Neurotensin (trifluoroacetate salt)1mg>95.00%Cas No. N/AC78H121N21O20?XCF3COOH

Orexin B (human) (trifluoroacetate salt)500μg>95.00%Cas No. N/AC123H212N44O35S?XCF3COOH

PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)500μg>95.00%Cas No. N/AC121H193N33O31S?XCF3COOH

Dopamine 3-O-Sulfate500 μg 1 mg>95.00%Cas No. 51317-41-0C8H11NO5S

GGTI 2133 (trifluoroacetate salt)500 μg 1 mg>95.00%Cas No. 1217480-14-2C27H28N4O3.XCF3COOH

Janthitrem A500 μg 2.5 mg>95.00%Cas No. 73561-89-4C37H47NO6

Isoreserpiline1mg 5mg>95.00%Cas No. 572-67-8C23H28N2O5