性能参数

产品名称

Methyl protodioscin

规格

10mg

货号

GOY-Y3275

 含量

>98.00%

CAS

54522-52-0

别名

化学名

分子式

C52H82O22

分子量

分子量 1063.23

溶解度

≥ 53.15mg/mL in DMSO

储存条件

4°C, protect from light

General tips

用途

仅供科研

价格

电询

详细内容

Methyl protodioscin(NSC-698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest.IC50 value:Target: in vitro: MPD showed growth inhibitory effects in A549 cells in a dose- and time-dependent manner. The significant G2/M cell cycle arrest and apoptotic effect were also seen in A549 cells treated with MPD. MPD-induced apoptosis was accompanied by a significant reduction of mitochondrial membrane potential, release of mitochondrial cytochrome c to cytosol, activation of caspase-3, downregulation of Bcl-2, p-Bad, and upregulation of Bax [1]. In THP-1 macrophages, MPD increases levels of ABCA1 mRNA and protein in dose- and time-dependent manners, and apoA-1-mediated cholesterol efflux. MPD also decreases the gene expressions of HMGCR, FAS and ACC for cholesterol and fatty acid synthesis [2].

(甲硫基)乙酸乙酯  4455-13-4  1,3-[2H,4H]-异喹啉二酮  4456-77-3

4-氟-2-硝基苯甲醚  445-83-0  2,4,5-**氧基苯甲醛  4460-86-0

4-氟-3-硝基甲苯  446-11-7  2,4,5-三氟苯甲酸  446-17-3

2-氟苯丙酮  446-22-0  4-氯-2-氟苯甲酸  446-30-0

4-氨基-2-氟苯甲酸  446-31-1  2-溴-3-氟苯甲醚  446-59-3

2-氯-4,6-二甲基嘧啶  4472-44-0  2-氯?

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