性能参数

产品名称

Schisandrin C

规格

20mg

货号

GOY-Y3276

 含量

>98.00%

CAS

61301-33-5

别名

化学名

分子式

C22H24O6

分子量

分子量 384.42

溶解度

DMF: 30 mg/ml,DMSO: 30 mg/ml

储存条件

General tips

用途

仅供科研

价格

电询

详细内容

Schisandrin C is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.IC50 value:Target: in vitro: Schisandrin C inhibited cell growth in a dose-dependent manner, which was associated with the induction of G1 arrest of the cell cycle and apoptosis. Schisandrin C induced G1 arrest was correlated with down-regulation of cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, inhibition of phosphorylation of retinoblastoma protein (pRB), and up-regulation of the Cdk inhibitor p21(WAF1/CIP1). In addition, schisandrin C-induced apoptosis was associated with down-regulation of expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL, proteolytic activation of caspase-3 and -9, and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). Furthermore, schisandrin C-induced apoptosis was significantly inhibited by a caspase-3 specific inhibitor z-DEVD-fmk [1]. Schisandrin C was found to reduce nitric oxide (NO) production from LPS-stimulated Raw 264.7 cells. Pre-treatment of Raw 264.7 cells with gomisin J, gomisin N, or schisandrin C reduced the expression of mRNA and the secretion of pro-inflammatory cytokines [2].

N-苄氧羰基-D-天冬酰胺  4474-86-6  丙烯酰氧乙基**基氯化铵  44992-01-0

6,11-二氢二苯并[b,e]氧杂卓-11-酮  4504-87-4  2-溴-5-氟苯甲醚  450-88-4

邻氯三氟甲氧基苯  450-96-4  3-氟苯甲酸乙酯  451-02-5

2,3-二氟苯甲酸  4519-39-5  2,3-二氟苯胺  4519-40-8

2-溴-4-氟苯甲醚  452-08-4  BOC-L-谷氨酸5甲酯  45214-91-3

3-溴-4-氟甲苯  452-62-0?

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