性能参数

产品名称

Torin 2

规格

10mM (in 1mL DMSO) 10mg 50mg 200mg

货号

GOY-Y3257

 含量

>98.00%

CAS

1223001-51-1

别名

化学名

9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2-one

分子式

C24H15F3N4O

分子量

分子量 432.41

溶解度

≥ 21.6mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Torin2 is a potent, selective and orally available inhibitor of mTOR with EC50 value of 0.25nM [1].

Torin2 is a highly potent and selective mTOR inhibitor. It is easier to produce than its lead compound Torin1 and displays improved pharmacokinetic properties. Torin2 is predicted to engage in hydrogen bonds with V2240 and Y2225 of a homology model of mTOR. It also form two hydrogen bonds between the aniline amino group of it with D2195 and D2357, making it more potent than Torin1. Besides that, Torin2 shows excellent overall selectivity and has strong binding to mTOR, CSNK1E, several PI3Ks, CSF1R and MKNK2. Torin2 exerts 800-fold cellular selectivity relative to inhibition of PI3K and other protein kinases. Moreover, Torin2 shows good bioavailability and exposure in vivo [1].

左对羟基苯甘氨酸甲酯  37763-23-8  Boc-D-脯氨酸  37784-17-1

(3-溴丙基)**基溴化铵  3779-42-8  4,5-二甲基-1,3-二氧杂环戊烯-2-酮  37830-90-3

4-氯烟酸乙酯盐酸盐  37831-62-2  五氟丙酸钠盐  378-77-8

3,5-二叔丁基水杨醛  37942-07-7  4-氨基-N-甲基苄胺  38020-69-8

4-(N-BOC-氨基)苯硼酸  380430-49-9  二乙胺基三氟化硫  38078-09-0

2-羟基-6?

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MDL 7222210 mg>99.00%Cas No. 40796-97-2C15H17Cl2NO2

Nabumetone-d31 mg>99.00%Cas No. 1216770-08-9C15H13D3O2

Netupitant-d61mg>99.00%Cas No. 2070015-31-3C30H26D6F6N4O

Olopatadine-d3 (hydrochloride)1 mg>99.00%Cas No. 1331635-21-2C21H20D3NO3.HCl