性能参数

产品名称

Pantoprazole

规格

 100mg 500mg

货号

GOY-Y3280

 含量

>98.00%

CAS

102625-70-7

别名

化学名

分子式

C16H15F2N3O4S

分子量

分子量 383.37

溶解度

≥ 17.95mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Pantoprazole is an inhibitor of H+/K+-ATPase [1].

Pantoprazole inhibits the activity of H+/K+-ATPase proton pumb in the parietal cells of gastric mucosa. This inhibition affects the acid secretion and thus, pantoprazole are used as drugs for the treatment of various acid-related disorders. Pantoprazole is activated slowly. The activated sulfonamide of pantoprazole binds to Cys813 and Cys822 of the pumb and inhibits acid secretion selectively. Pantoprazole inhibited lysosomal acidification with IC50 value of 194 μM. The pKa values of pantoprazole are 3.83 (pKa1) and 0.11 (pKa2). Besides that, pantoprazole also shows antibacterial effects on Helicobacter pylori [1, 2].

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亚麻酸  463-40-1  对氯苯乙酰腈  4640-66-8

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