性能参数

产品名称

Taltobulin hydrochloride

规格

10mM*1 mL in DMSO 5mg 10mg 50mg

货号

GOY-Y3327

 含量

>99.00%

CAS

N/A

别名

N/A

化学名

N/A

分子式

C27H44ClN3O4

分子量

分子量 510.11

溶解度

DMSO: ≥ 100 mg/mL (196.04 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1].

Taltobulin (HTI-286; 0.2-7.3 nM; 3 days) inhibits the growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) with an average IC50 of 2.5±2.1 nM and a median value of 1.7 nM[1]. Cell Proliferation Assay[1] Cell Line: Leukemia CCRF-CEM cell line; ovarian 1A9 cell line; NSCLC A549 and NCI-H1299 cell lines; breast MX-1W and MCF-7 cell lines; colon HCT-116, DLD-1, Colo205, KM20, SW620, S1, HCT-15 and Moser cell lines; melanoma A375, Lox and SK-Mel-2 cell lines

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反-(1R,2R)-N,N\\\'-二甲基1,2-环己烷二胺  67579-81-1  五碳醛糖  6763-34-4

4-乙基-4,10-二羟基-1H-吡喃[3',4':6,7]吲哚[1,2-B]喹啉-3,14(4H,12H)-二酮  67656-30-8  二甲基砜  67-71-0

叔丁基氯化镁  677-22-5  4-苄氧基溴苯  6793-92-6

1-(4-溴苯基)哌嗪盐酸盐  68104?

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