性能参数

产品名称

Topotecan HCl

规格

10mM (in 1mL DMSO) 10mg 50mg 100mg

货号

GOY-Y3329

 含量

>99.00%

CAS

119413-54-6

别名

N/A

化学名

(S)-10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride

分子式

C23H24ClN3O5

分子量

分子量 457.91

溶解度

≥ 22.9mg/mL in DMSO

储存条件

4°C, protect from light

General tips

用途

仅供科研

价格

电询

详细内容

Topotecan HCl（SKF104864）is an inhibitor of topoisomerase 1 and semisynthetic analogue of camptothecin [1].

Topotecan HCl（SKF104864）has been reported to have a potent antitumor activity against tumors in murine models. In addition, Topotecan HCl has also shown the potent effect against intravenously implanted P388 leukemia and both intravenously and subcutaneously implanted Lewis lung carcinoma. Topotecan HCl has noted the activity against subcutaneously implanted solid tumors including chemorefractory tumors and human colon carcinoma xenograft HT-29. Topotecan HCl has been found to induce regressions in the lung tumor model (Lewis lung carcinoma and B16 melanoma), compared to camptothecin and 9-amino-camptothecin. In the preclinical toxicology studies, Topotecan HCl has been revealed to have a concentration-dependent, reversible and limited toxoicity to rapidly proliferation tissues such as bone marrow and gastro-intestinal epithelium [1].

乙炔锂乙二胺络合物  6867-30-7  2,4-二氯苯硼酸  68716-47-2

4-甲氧基-3-甲基苯甲酸  1819002  硼酸三丁酯  688-74-4

6-羟基嘌呤  68-94-0  1-溴-2-氟-4-三氟甲氧基苯  168971-68-4

噻吩-2-碳酸酯  68986-76-5  甲基丙烯酸钾  6900-35-2

间碘苯腈  69113-59-3  DL-苹果酸  6915-15-7

苄基氯化镁  6921-34-2  1,3二氯-1,1,3,3-四异丙基二硅氧烷  69304-?

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