性能参数

产品名称

Sunitinib

规格

10mM (in 1mL DMSO) 100mg 500mg 1g 2g

货号

GOY-Y3336

 含量

>99.00%

CAS

557795-19-4

别名

N/A

化学名

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

分子式

C22H27FN4O2

分子量

分子量 398.47

溶解度

≥ 19.9mg/mL in DMSO with gentle warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Sunitinib is an oral, multi-targeted and small-molecule inhibitor of receptor tyrosine kinase (RTK) [1].

Sunitinib is a RTK inhibitor against vascular endothelial growth factor receptors (VEGFR1-3), platelet-derived growth factor receptors (PDGFRα and PDGFRβ ), stem cell factor receptor (c-kit), glial cell-line derived neurotrophic factor receptor(RET). Sunitinib has been reported to inhibit the growth in five NPC cell lines (HK1, CNE-2, HON E-1, CNE-1 and C666-1) with the IC50 values of 2.06 ± 0.29μM, 3.45 ± 0.11μM, 4.07 ± 1.07μM, 2.60 ± 0.38 and 7.57 ± 1.74μM, respectively. Apart from these, Sunitinib has been observed to induce apoptosis in NPC cells as well as induce cell cycle arrest at the G0 /G1 phase in HONE-1 and CNE-2 cells. In vivo, Sunitinib treatment could induce a significant reduction in MVD in CNE2 NPC xenograft [1].

3,5-双(三氟甲基)苯硼酸  73852-19-4  3,5-双三氟甲基苯甲酸  725-89-3

3-氨基-2-羟基苯乙酮  70977-72-9  3-氨基-6-甲基苯磺酰胺  1853127

3-氨基-4-吡啶羧酸  7579-20-6  3-胺基-1-金刚烷醇  702-82-9

3-苯基苯甲酸  716-76-7  3-碘苯甲醚  766-85-8

3-丁烯基溴化镁  1900605  3-环己基丙酸  701-97-3

3-甲氧基-4-甲基苯甲酸  7151-68-0  3-氯-1,2-苯并?

Roluperidone (CYR-101)2mg 5mg 10mg 50mg 100mg>99.50%Cas No. 359625-79-9C22H23FN2O2

S 380931mg 5mg 10mg 50mg 100mg>99.50%Cas No. 862896-30-8C17H24N2O2

Semagacestat (LY450139)10mM (in 1mL DMSO) 5mg 10mg 50mg 200mg>99.50%Cas No. 425386-60-3C19H27N3O4

SKF-82958 hydrobromide ((±)-SKF 82958 hydrobromide)5mg 10mg 25mg 50mg 100mg>99.50%Cas No. 74115-01-8C19H21BrClNO2

Substance P (1-7)(TFA)5mg 10mg 25mg 50mg 100mg>99.50%Cas No. N/AC43H66F3N13O12

Teriflunomide impurity 35 mg 10 mg 25 mg 50 mg 100 mg>99.50%Cas No. 1011244-72-6C14H11F3N2O

TBPB5mg 10mg 50mg 100mg 200mg>99.50%Cas No. 634616-95-8C25H32N4O