性能参数

产品名称

Sulforaphane

规格

10 mM * 1 mL in DMSO 10mg 25mg 50mg 100mg

货号

GOY-Y3337

 含量

>99.00%

CAS

4478-93-7

别名

SFN

化学名

1-isothiocyanato-4-(methylsulfinyl)-butane

分子式

C6H11NOS2

分子量

分子量 177.3

溶解度

≥ 67.6mg/mL in DMSO

储存条件

Store at -20°C, sealed storage, away from moisture and light

General tips

用途

仅供科研

价格

电询

详细内容

Sulforaphane is an isothiocyanate present naturally in widely consumed vegetables; has shown anticancer and cardioprotective activities.

Sulforaphane induces a cell cycle arrest in a dose-dependent manner, followed by cell death. This sulforaphane-induced cell cycle arrest was correlated with an increased expression of cyclins A and B1. Sulforaphane induces cell death via an apoptotic process. Sulforaphane inhibits the reinitiation of growth and diminishes cellular viability in quiescent colon carcinoma cells (HT29) and has a lower toxicity on differentiated CaCo2 cells[1]. Pre-treatment of H9c2 rat myoblasts with sulforaphane decreases the apoptotic cell number and the expression of pro-apoptotic proteins (Bax, caspase-3 and cytochrome c), as well as the doxorubicin-induced increase in mitochondrial membrane potential. Furthermore, sulforaphane increases the mRNA and protein expression of heme oxygenase-1, which consequently reduces the levels of reactive oxygen species (ROS, measured using MitoSOX Red reagent) in the mitochondria which are induced by doxorubicin[2].

Sulforaphane can block the formation of ammary tumors in Sprague-Dawley rats treated with single doses of 9,10-dimethyl-1,2-benzanthracene. Administration of sulforaphane reduces the incidence, multiplicity, and weights and delays the development of the mammary tumors evoked by a single dose of DMBA in female Sprague-Dawley rats[3].

3-氯-4-溴吡啶  73583-41-2  3-氯吡啶-4-甲醛  72990-37-5

3-羟基-4-硝基苯甲醛  704-13-2  3-溴-2-硝基苯胺  7138-15-0

3-溴-4-甲基苯甲酸  7697-26-9  3-溴-5-氯吡啶  73583-39-8

3-溴-7-氮杂吲哚  74420-15-8  3-溴噻吩-2-甲酸  7311-64-0

3-氧代-1-哌嗪羧酸叔丁酯  76003-29-7  3-乙酰吲哚  703-80-0

3-乙氧基丙酸乙酯  763-69-9  3-吲哚甲?

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