性能参数

产品名称

Monascuspiloin

规格

100μg 500μg

货号

GOY-Y3353

 含量

>95.00%

CAS

1011244-19-1

别名

N/A

化学名

N/A

分子式

C21H28O5

分子量

分子量 360.4

溶解度

储存条件

-20°C

General tips

用途

仅供科研

价格

电询

详细内容

Monascuspiloin is a fungal metabolite that has been found in M. pilosus M93-fermented rice.1 It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 μM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 μM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40 and 120 mg/kg.2

1.Chiu, H.-W., Fang, W.-H., Chen, Y.-L., et al.Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagyPLoS One7(7)e40462(2012) 2.Chen, R.-J., Hung, C.-M., Chen, Y.-L., et al.Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the Akt and AMPK signaling pathwaysJ. Agric. Food Chem.60(29)7185-7193(2012)

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