性能参数

产品名称

Marein

规格

5mg

货号

GOY-Y3443

 含量

>98.00%

CAS

535-96-6

别名

N/A

化学名

N/A

分子式

C21H22O11

分子量

分子量 450.39

溶解度

DMSO: soluble

储存条件

4°C, protect from light

General tips

用途

仅供科研

价格

电询

详细内容

Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects[1][2][3].

[1]. Baoping Jiang, et al. Protective effects of marein on high glucose-induced glucose metabolic disorder in HepG2 cells. Phytomedicine. 2016 Aug 15;23(9):891-900. [2]. Baoping Jiang, et al. Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells. Free Radic Res. 2016;50(11):1173-1187. [3]. B Orlikova, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805.

硫酸肼  10034-93-2  二水氯化钙  10035-04-8

1-苯并呋喃-5-甲醛  10035-16-2  N,N-二乙基乙二胺  100-36-7

4-甲基吡啶氧化物  1003-67-4  3-甲基吡啶氧化物  1003-73-2

二乙氨基乙醇  100-37-8  溴化苄  100-39-0

磷酸氢二钠  10039-32-4  次亚磷酸钠  10039-56-2

2-溴-4-氟苯胺  1003-98-1  乙基苯  100-41-4

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AC 18610 mg 50 mg>98.00%Cas No. 1421854-16-1C18H17F3O

16α-Hydroxyetiocholanolone1 mg 5 mg 10 mg>95.00%Cas No. 14167-50-1C19H30O3

16α-hydroxy Dehydroepiandrosterone1 mg 5 mg 10 mg>95.00%Cas No. 1232-73-1C19H28O3

11-Dehydrocorticosterone1mg 5mg 10mg>90.00%Cas No. 72-23-1C21H28O4

1α-Hydroxy-3-epi-vitamin D31 mg 5 mg 10 mg>99.00%Cas No. 58028-00-5C27H44O2