性能参数

产品名称

3-acetyl-11-keto-β-Boswellic Acid

规格

5mg 10mg

货号

GOY-Y3457

 含量

>98.00%

CAS

67416-61-9

别名

3-O-acetyl-11-keto-β-Boswellic acid,AKBA

化学名

(3α,4β)-3-(acetyloxy)-11-oxo-urs-12-en-23-oic acid

分子式

C32H48O5

分子量

分子量 512.7

溶解度

≤5mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

IC50: 1.5 μM

3-acetyl-11-keto-β-Boswellic Acid, as known as AKBA, is a pentacyclic triterpene that suppresses 5-lipoxygenase in a selective, nonredox, enzyme-directed, and noncompetitive manner. Also, AKBA inhibits topoisomeraseⅠ and NF-κB signaling. AKBA has been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.

In vitro: AKBA exerted a time- and concentration -dependent cytotoxicity on androgen-independent prostate cancer cells. AKBA blocked proliferation and elicited apoptosis in the chemoresistant and androgen-independent human PC-3 prostate cancer cells by the release of mitochondrial cytochrome c and DNA fragmentation. Also, AKBA concentration-dependently inhibited NF-κB signaling, yet it did not directly affect the NF-κB binding to DNA. Additionally, AKBA suppressed inhibitor κB kinase and NF-κB-dependent antiapoptotic gene products in PC-3 cells [1].

In vivo: PC-3 xenotransplanted male NMRI/nu-nu mice were injected intraperitoneally at 100 μmol/kg daily for three weeks. AKBA dampened growth and proliferation of PC-3 xenografts in nude mice and elicited apoptosis. Moreover, compared with the control group, AKBA reduced the tumor volume and the invasiveness of the tumor into the surrounding tissues [1].

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正丙基溴  106-94-5  3-溴丙烯  106-95-6

3-溴丙炔  106-96-7  1-溴-2-氯乙烷  107-04-0

丙烯酰氯  107-05-1  1,2-二氯乙烷  107-06-2

2-氯乙醇  107-07-3  3,3-二甲基-1-丁酸  1070-83-3

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