性能参数

产品名称

CTPB

规格

1mg 5mg

货号

GOY-Y3485

 含量

>98.00%

CAS

586976-24-1

别名

N/A

化学名

N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl-benzamide

分子式

C31H43ClF3NO2

分子量

分子量 554.1

溶解度

≤15mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

CTPB is a selective activator of p300 HAT activity [1].

CREB binding protein (CBP) and E1A binding protein p300, also known as p300 are functionally related transcriptional co-activators (CoAs) and histone acetyltransferases (HATs). The p300/CBP is a global transcriptional coactivator, which plays a critical role in cell cycle control, differentiation, and apoptosis. Mutations in p300/CBP are associated with different human cancers and other human diseases [1][2].

CTPB, also known as N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benza-mide, is an amide derivative that selectively activates p300 HAT activity. CTPB directly binds p300 [2]. CTPB exhibited an enhancement in the p300 HAT activity concentration-dependently with maximal activation at 275 μM. In the presence of p300, CTPB resulted in the gradual increase in the acetylation of both histones H3 and H4, peaking at 200 μM. Further increase in the concentration of CTPB reduced the HAT activity, could be due to an alteration in the reaction condition affecting the efficiency of the HAT. CTPB didn’t alter PCAF HAT or histone deacetylase activity [1].

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2,5-二甲基吡嗪  123-32-0  丙醛  123-38-6

N-甲基甲酰胺  123-39-7  4-羟基-4-甲基-2-戊酮  123-42-2

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