性能参数

产品名称

Dot1L-IN-1

规格

250mg 500mg

货号

GOY-Y3487

 含量

>98.00%

CAS

2088518-50-5

别名

N/A

化学名

N/A

分子式

C32H36ClN9O2S

分子量

分子量 646.21

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Dot1L-IN-1 is a highly potent, selective and structurally novel Dot1L inhibitor with a Ki of 2 pM.

Dot1L-IN-1 potently suppresses H3K79 dimethylation (IC50 = 3 nM), the direct product of the Dot1Lcatalyzed reaction, as well as the activity of the HoxA9 promoter (IC50 = 17 nM) in HeLa and Molm-13 cells, respectively[1]. Dot1L-IN-1 effectively inhibits proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC50 = 5 nM)[1].

[1]. M?bitz H, et al. Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach. ACS Med Chem Lett. 2017 Feb 14;8(3):338-343.

二烯丙基胺  124-02-7  己二酸  124-04-9

1,6-已烷二胺  124-09-4  十二烷基伯胺  124-22-1

二甲胺  124-40-3  甲醇钠  124-41-4

盐酸乙脒  124-42-5  过氧化脲  124-43-6

硝酸脲  124-47-0  2-氨基-2-甲基-1-丙醇  124-68-5

百里酚酞  125-20-2  4-溴甲基四氢吡喃  125552-89-8

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