Hesperadin hydrochloride
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产品名称:
Hesperadin hydrochloride
产品型号:
GOY-Y3505
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-08
简单介绍
Hesperadin hydrochlorideSoluble in DMSO
Hesperadin hydrochloride
的详细介绍
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性能参数
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产品名称
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Hesperadin hydrochloride
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规格
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10 mg 50 mg
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货号
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GOY-Y3505
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含量
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>98.00%
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CAS
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N/A
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别名
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N/A
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化学名
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N/A
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分子式
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C29H32N4O3S.HCl
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分子量
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分子量 553.12
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溶解度
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Soluble in DMSO
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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ATP-competitive inhibitor of Aurora B kinase (IC50 = 250 nM). Prevents chromosome alignment and segregation; also induces polyploidy and prevents histone H3-Ser10 phosphorylation. Overrides the spindle assembly checkpoint and induces mitotic exit in monastrol- and taxol-treated HeLa cells.
Hauf et al (2003) The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J.Cell.Biol. 161 281 PMID:12707311 |Jetton et al (2009) The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms. Mol.Microbiol. 72 442 PMID:19320832 |Sessa et al (2005) Mechanism of Aurora B activation by INCENP and inhibition by Hesperadin. Mol.Cell. 18 379 PMID:15866179
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