Methapyrilene (hydrochloride)
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产品名称:
Methapyrilene (hydrochloride)
产品型号:
GOY-Y3519
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-08
简单介绍
Methapyrilene (hydrochloride)DMF: 15 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
Methapyrilene (hydrochloride)
的详细介绍
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性能参数
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产品名称
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Methapyrilene (hydrochloride)
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规格
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100mg 250mg
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货号
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GOY-Y3519
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含量
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>98.00%
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CAS
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135-23-9
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别名
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N/A
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化学名
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N/A
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分子式
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C14H19N3S?HCl
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分子量
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分子量 297.8
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溶解度
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DMF: 15 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
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储存条件
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-20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Methapyrilene is a histamine H1 receptor antagonist (Ki = 4.5 nM) and non-genotoxic carcinogen.1,2 Dietary administration of methapyrilene (0.1%) induces liver tumors in rats, with greater than 50% of rats incurring distant metastases.3 It decreases the acetylation of histone 3 lysine 9 (H3K9) and H3K56, as well as the di- and trimethylation of H3K4 and H4K20, respectively, in rat liver when administered at 40 mg/kg per day for six weeks.2 Methapyrilene also increases 4-hydroxy nonenal (4-NHE) protein adducts in rat liver. Formulations containing methapyrilene were previously used as sleep aids.
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