Methylstat (hydrate)
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产品名称:
Methylstat (hydrate)
产品型号:
GOY-Y3534
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-08
简单介绍
Methylstat (hydrate)DMF: 25,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:40): 0.02 mg/ml
Methylstat (hydrate)
的详细介绍
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性能参数
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产品名称
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Methylstat (hydrate)
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规格
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1mg 5mg 10mg
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货号
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GOY-Y3534
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含量
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>98.00%
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CAS
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N/A
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别名
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N/A
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化学名
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N/A
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分子式
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C28H31N3O6?H2O
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分子量
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分子量 523.6
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溶解度
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DMF: 25,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:40): 0.02 mg/ml
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD3 with IC50 values of approximately 4.3, 3.4, 5.9, 10, and 43 μM, respectively, in an in vitro assay. Methylstat inhibits growth of the JMJD2C-sensitive esophageal cancer cell line KYSE150 with a GI50 of 5.1 μM, whereas the free acid of methylstat did not inhibit cell growth up to 100 μM. Methylstat induces histone hypermethylation at multiple sites in a concentration-dependent manner (EC50 for H3K4me3 and H3K9me3 = 10.3 and 8.6 μM in KYSE150 cells and 6.7 ad 6.3 μM in MCF-7 cells, respectively).
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甲烷?
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