性能参数

产品名称

5-Azacytidine

规格

10mM (in 1mL DMSO) 250mg 1g

货号

GOY-Y3538

 含量

>98.00%

CAS

320-67-2

别名

N/A

化学名

4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one

分子式

C8H12N4O5

分子量

分子量 244.2

溶解度

≥ 12.21mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

5-Azacytidine (also known as 5-AzaC), a compound belonging to a class of cytosine analogues, is a DNA methyl transferase (DNMT) inhibitor that exerts potent cytotoxicity against multiple myeloma (MM) cells, including MM.1S, MM.1R, RPMI-8266, RPMI-LR5, RPMI-Dox40 and Patient-derived MM, with the half maximal inhibition concentration IC50 values of 1.5 μmol/L, 0.7 μmol/L, 1.1 μmol/L, 2.5 μmol/L, 3.2 μmol/L and 1.5 μmol/L respectively [1].

5-Azacytidine incorporates into cellular DNA and/or RNA, subsequently sequesters DNMT and forms a covalent bond between C6 of 5-Azacytidine and cysteine thiolate of DNMTs resulting in depletion of DNMT activity in cells and demethylation of cellular DNA [1].

2-溴苯丙酮  2114-00-3  6-溴-2-吡啶羧酸  21190-87-4

2-甲基-5-硝基吡啶  21203-68-9  L-扁桃酸甲酯  21210-43-5

吲哚-4-羧酸  2124-55-2  右旋樟脑-10-磺酰氯  21286-54-4

Boc-O-苄基-L-酪氨酸  2130-96-3  L-甲酸盐酸盐  2133-33-7

L-脯氨酸甲酯盐酸盐  2133-40-6  2-氯-3-氟苯胺  21397-08-0

3'-溴苯乙酮  2142-63-4  2'-氯苯基乙酮  214defaul

4-乙酰氧基-3-甲氧...4-Acetoxy-3-methoxycinnamic acid (HPLC...2596-47-61G

4-氟苯基醋酸酯4-Fluorophenyl acetate,≥97.0%405-51-65G

四乙二醇二对甲苯磺...Tetraethylene Glycol Di-p-tosylate,97%37860-51-810G

溴代三(二甲基氨基)...Bromotris(dimethylamino)phosphonium He...50296-37-21G

1,1'-羰基二吡咯CDP,98%81759-25-31G

1,5-戊二醇1,5-Pentanediol,≥97.0%111-29-5100ML