Lysine-specific Demethylase Inhibitor (1C)
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产品名称:
Lysine-specific Demethylase Inhibitor (1C)
产品型号:
GOY-Y3606
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-09
简单介绍
Lysine-specific Demethylase Inhibitor (1C)Soluble in DMSO
Lysine-specific Demethylase Inhibitor (1C)
的详细介绍
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性能参数
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产品名称
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Lysine-specific Demethylase Inhibitor (1C)
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规格
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1mg 5mg 10mg
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货号
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GOY-Y3606
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含量
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>98.00%
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CAS
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927019-63-4
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别名
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KDM1 Inhibitor I|LSD1 Inhibitor
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化学名
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N,N'-dimethyl-15-(methylimino)-2,6,10,14,16-pentaazaheptadecanimidamide
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分子式
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C15H36N8
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分子量
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分子量 328.5
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溶解度
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Soluble in DMSO
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Lysine-specific Demethylase Inhibitor (1C) is a lysine-specific demethylase inhibitor.
Lysine-specific demethylase 1 (LSD1) is the first of several protein lysine demethylases identified. Through a FAD-dependent oxidative reaction, LSD1 could specifically remove histone H3K4me2 to H3K4me1 or H3K4me0. When forming a complex with androgen receptor, LSD1 alters its substrates to H3K9me2. The LSD1 complex regulates a coordinated histone modification switch via enzymatic activities and histone modification readers.
In vitro: Lysine-specific Demethylase Inhibitor (1C) was identified as a bisguanidine polyamine analogue exhibiting noncompetitive and specific LSD1 inhibition, with 14.1% in vitro LSD1 activity at 10 μM. Lysine-specific Demethylase Inhibitor (1C) at 0.25 μM to 10 μM could significantly and dose-dependently increase methylation at the histone 3 lysine 4 chromatin mark, H3K4me1 and H3K4me2, without affecting global H3K9me2 levels in HCT116 human colon carcinoma cells. Lysine-specific Demethylase Inhibitor (1C) could also induce expression of several epigenetically silenced genes, such as SFRP1, SFRP4, SFRP5, and GATA5, particularly in the case of SFRP4 and SFRP5 [1].
In vivo: Currently, there is no animal in vivo data reported.
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