性能参数

产品名称

Nicotinamide riboside

规格

5mg  10mg 25mg

货号

GOY-Y3615

 含量

>98.00%

CAS

1341-23-7

别名

N/A

化学名

N/A

分子式

C11H15N2O5

分子量

分子量 255.3

溶解度

Soluble in Water

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Nicotinamide riboside is a riboside form of nicotinamide that is found in trace amounts in yeast-containing and milk-derived products. It is a precursor of NAD+ and a source of vitamin B3 (niacin). Nicotinamide riboside increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1,000 μM. It also decreases acetylation of FOXO1 and SOD2, which are substrates of sirtuin 1 (SIRT1) and SIRT3, respectively, but not the SIRT2 substrate tubulin, indicating nicotinamide riboside selectively enhances SIRT1 and 3 deacetylase activity. Nicotinamide riboside (400 mg/kg per day) increases NAD+ levels in liver and skeletal muscle and prevents body weight gain in mice fed a high-fat diet. It also increases NAD+ in the cerebral cortex and reduces cognitive deterioration in a transgenic mouse model of Alzheimer's disease.

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