性能参数

产品名称

I-BET-762

规格

10mM (in 1mL DMSO) 5mg 10mg 50mg

货号

GOY-Y3713

 含量

>98.00%

CAS

1260907-17-2

别名

N/A

化学名

2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide

分子式

C22H22ClN5O2

分子量

分子量 423.9

溶解度

≥ 21.195mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

I-BET-762 is a highly potent inhibitor of BET with IC50 values of 32.5–42.5 nM [1].

I-BET-762 is found to have high affinity with BET (Kd of 50.5–61.3 nM). It binds to the acetyl-lysine (AcK)-binding pocket of BET and competes with AcK. The structure of I-BET-762 allows it to bind with BET in ratio of 2:1 results in the high affinity of it. I-BET-762 also has high selectivity, it has no interaction with other bromodomain-containing proteins. I-BET-762 is reported to downregulate the expression of the genes which are induced by LPS, thus causing the decreased expression of LPS-inducible cytokines and chemokines. In vivo assay shows that I-BET-762 has the anti-inflammatory potential. Treatment of I-BET-762 can cure the mice which have started to develop symptoms of inflammatory disease [1].

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D-叔亮氨酸  26782-71-8  D-谷氨酸二甲酯盐酸盐  27025-25-8

4-溴-2-氯碘苯  31928-47-9  [(二氟甲基)磺?；鵠苯  1535-65-5

1-(3-三氟甲基苯基)哌嗪  15532-75-9  2-甲氧基-5-吡啶硼酸  163105-89-3

维拉佐酮  163521-12-8  甲磺酸帕珠沙星  163680-77-1

四甲基氟代脲六氟磷酸酯  164298-23-1  1

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3-甲基-3-苯基缩水...Ethyl 3-methyl-3-phenylglycidate,≥98%77-83-825ML

苯甲醛丙二醇缩醛Benzaldehyde propylene glycol acetal,...2568-25-4100ML

香茅醛(±)-Citronellal,≥95.0%106-23-025ML

铃兰醛2-(4-tert-Butylbenzyl)propionaldehyde,...80-54-625ML

羟基香茅醛Hydroxycitronellal,≥95%107-75-55ML