性能参数

产品名称

Belinostat 

规格

10mM (in 1mL DMSO)10mg 50mg 100mg 200mg

货号

GOY-Y3760

 含量

>98.00%

CAS

414864-00-9

别名

PXD-101, PXD 101, PX105684, PX-105684

化学名

(E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide

分子式

C15H14N2O4S

分子量

分子量 318.35

溶解度

≥ 15.92 mg/mL in DMSO, ≥ 44.1 mg/mL in EtOH with ultrasonic

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Belinostat (also known as PXD101) is a novel and potent hydroxamate-type inhibitor of histone deacetylase (HDAC) that inhibits the activity of HDAC in Hela cell extracts with 50% inhibition concentration IC50 value of 27 nM. Belinostat has been found to significantly increase the acetylation of histones H3 and H4 and exerts cytotoxicity in a wide range of tumor cell lines. In the treatment of urothelial carcinoma cell lines, belinostat dose-dependently inhibits proliferation in 5637, T24, J82 and RT4 cells with IC50 values of 1.0 μM, 3.5 μM, 6.0 μM and 10 μM respectively; while, in prostate cancer cell lines, it inhibits cancer cell growth with IC50 values ranging from 0.5 to 2.5 μM.

环戊基甲酰氯  4524-93-0  4-氨基-3-氟苯甲酸  455-87-8

(R)-(+)-1-(4-溴苯基)乙胺  45791-36-4  2-溴噁唑-4-羧酸乙酯  460081-20-3

N-Boc-O-苄基-D-丝氨酸  47173-80-8  3-氨基丙酰胺  4726-85-6

4-乙基苯甲醛  4748-78-1  西他列汀  486460-32-6

1-金刚烷乙酸  4942-47-6  对异丙基苯硫酚  4946-14-9

苯丁酮  495-40-9  3,5-二氯苯肼  3994

2,4-Pyridinedicarboxylic Acid10mM (in 1mL DMSO)5g>98.00%Cas No. 499-80-9C7H5NO4

2-hexyl-4-Pentynoic Acid250mg 1g>98.00%Cas No. 96017-59-3C11H18O2

1,2,3,4,5,6-Hexabromocyclohexane10mM (in 1mL DMSO)50mg>98.00%Cas No. 1837-91-8C6H6Br6

4-HQN10mM (in 1mL DMSO)50mg>98.00%Cas No. 491-36-1C8H6N2O

Alexidine dihydrochloride10mM (in 1mL DMSO)50mg>98.00%Cas No. 1715-30-6C26H56N10.2HCl

AS835110mg 50mg>98.00%Cas No. 796-42-9C17H13N3O2

Amodiaquine dihydrochloride dihydrate100mg 500mg>98.00%Cas No. 6398-98-7C20H28Cl3N3O3