性能参数

产品名称

dTRIM24

规格

10mM*1mL in DMSO5mg 10mg 25mg 50mg 100mg

货号

GOY-Y3861

 含量

>98.00%

CAS

2170695-14-2

别名

N/A

化学名

N/A

分子式

C55H68N8O13S2

分子量

分子量 1113.3

溶解度

Ethanol: < 1 mg/mL (insoluble)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC. TRIM24[2].

dTRIM24 is a degrader of TRIM24 bromodomain. Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24. The anti-proliferative consequences of chemical degradation versus inhibition of TRIM24 are assessed. Growth over time is determined for MOLM-13 cells treated with dTRIM24, IACS-9571, VL-269, and eTRIM24. dTRIM24 suppresses growth to a greater extent than does IACS-9571, accompanied by apoptosis measured as enhanced PARP cleavage. In agreement with a sustained proliferative defect observed following dTRIM24 treatment, near-complete degradation of TRIM24 is observed in dTRIM24-treated cells throughout the duration of the experiment[2].

[1]. Gechijian LN, et al. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat Chem Biol. 2018 Apr;14(4):405-412.

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