性能参数

产品名称

MS31 trihydrochloride

规格

5mg 10mg 50mg 100mg 200mg 500mg

货号

GOY-Y3883

 含量

>98.00%

CAS

N/A

别名

N/A

化学名

N/A

分子式

C20H30Cl3N3O2

分子量

分子量 450.83

溶解度

DMSO: 62.5 mg/mL (138.63 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells[1].

[1]. Xiong Y, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1(SPIN1). J Med Chem. 2019 Jul 24.

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