性能参数

产品名称

(-)-JQ1

规格

2mg 5mg 10mg 50mg 100mg 200mg 500mg

货号

GOY-Y3892

 含量

>98.00%

CAS

1268524-71-5

别名

(-)-JQ1

化学名

(R)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

分子式

C23H25ClN4O2S

分子量

分子量 456.99

溶解度

≥ 22.8mg/mL in DMSO, ≥ 46.9 mg/mL in EtOH with ultrasonic

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

(-)-JQ1 is the stereoisomer of JQ1, a cell-permeable small-molecule inhibitor of BET bromodomain that competitively binds to acetyl-lysine recognition motifs. JQ1 is a novel thieno-triazolo-1,4-diazepine with an appended and bulky t-butyl ester functional group at C6 position in its chemical structure, which allows for additional pendant group diversity and mitigates binding to the central benzodiazepine receptor. JQ1 competitively binds to the bromodomain displacing the BRD4 fusion oncoprotein from chromatin, which induces squamous differentiation and specific anti-proliferative effect in BRD4-dependent cell lines and patient-derived xenograft models. However, study results have shown that (-)-JQ1 fails to significantly interact with any bromodomain tested and exhibits inhibition against BRD4(1) with 50% inhibition concentration IC50 value of 10,000 nM.

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5-氟-2-硝基苯甲醛5-Fluoro-2-nitrobenzaldehyde,98%395-81-31G

5-氟-2-甲基苯甲醛5-Fluoro-2-methylbenzaldehyde,96%22062-53-91G

4-氟-3-甲基苯甲醛4-Fluoro-3-methylbenzaldehyde,97%135427-08-61G

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