CPTH2 (hydrochloride)
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产品名称:
CPTH2 (hydrochloride)
产品型号:
GOY-Y3943
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-09
简单介绍
CPTH2 (hydrochloride)≤5mg/ml in ethanol;16mg/ml in DMSO;5mg/ml in dimethyl formamide
CPTH2 (hydrochloride)
的详细介绍
性能参数
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产品名称
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CPTH2 (hydrochloride)
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规格
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5mg 10mg
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货号
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GOY-Y3943
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含量
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>98.00%
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CAS
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2108899-91-6
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别名
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化学名
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2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone, monohydrochloride
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分子式
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C14H14ClN3S ? HCl
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分子量
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分子量 328.3
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溶解度
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≤5mg/ml in ethanol;16mg/ml in DMSO;5mg/ml in dimethyl formamide
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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CPTH2 is an inhibitor of HAT activity of Gcn5.
Histone acetyltransferases (HATs) has been identified to add the acetyl group on the specific lysine of histone H3 and H4 N-termini, and such signatures are able to increase the accessibility of the underlying chromatin at specific genes or over vast regions of the genome. Gcn5p is a chimeric protein made up of a number of functional domains.
In vitro: Previous study identified a novel molecule named CPTH2, which was selected based on its inhibitory effect on the growth of a gcn5Delta strain. This study indicated a specific chemical-genetic interaction between CPTH2 and HAT Gcn5p, suggesting that CPTH2 could inhibit the dependent functional network of Gcn5p. In addition, CPTH2 was found to be able to inhibit an in-vitro HAT reaction, which could be reverted by increasing concentration of histone H3 [1].
In vivo: In vivo, CPTH2 could decrease the acetylation of bulk histone H3 at the specific H3-AcK14 site [1].
Clinical trial: Up to now, CPTH2 is still in the preclinical development stage.
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