商品属性：
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产品名称
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phospho-VAV1 (Tyr174)抗体
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英文名称
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phospho-VAV1 (Tyr174)
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产品规格
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50ul 100ul 200ul
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产品货号
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GOY-01K1584
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产品分类
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抗体 / 一抗
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交叉反应
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Human, Mouse, Rat, Dog, Pig, Horse
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保存条件
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Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
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标记
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Unconjugated
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抗体来源
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Rabbit
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抗体类型
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Polyclonal
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研究领域
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肿瘤 染色质和核信号 信号转导 转录调节因子 激酶和磷酸酶 G蛋白偶联受体 T-**细胞
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蛋白细胞定位
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细胞浆,细胞膜
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纯化方法
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affinity purified by Protein A
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性状
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Liquid
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浓度
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1mg/ml
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储存液
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0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
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发货地
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上海
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背景资料
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This e is a member of the VAV e family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this e. [provided by RefSeq, Apr 2012].
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