产品名称

C4a+C4b抗体

英文名称

C4a+C4b

产品规格

50ul  100ul 200ul 

产品货号

GOY-01K1184

产品分类

抗体 / 一抗

交叉反应

Human

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

标记

Unconjugated

抗体来源

Rabbit

抗体类型

Polyclonal

研究领域

细胞生物

蛋白细胞定位

细胞膜,细胞外基质

纯化方法

affinity purified by Protein A

性状

Liquid

浓度

1mg/ml

储存液

 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

发货地

上海

背景资料

This e encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the anti-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This e localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this e cluster t, such that individuals may have 1, 2, or 3 copies of this e. Two transcript variants encoding different isoforms have been found for this e. [provided by RefSeq, Nov 2011].