商品属性：
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产品名称
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Constitutive androstane receptor抗体
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英文名称
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Constitutive androstane receptor
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产品规格
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50ul 100ul 200ul
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产品货号
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GOY-01K0296
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产品分类
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抗体 / 一抗
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交叉反应
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Human, Chimpanzee
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保存条件
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Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
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标记
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Unconjugated
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抗体来源
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Rabbit
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抗体类型
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Polyclonal
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研究领域
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细胞生物 转录调节因子 细胞膜受体
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蛋白细胞定位
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细胞核,细胞浆,细胞膜
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纯化方法
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affinity purified by Protein A
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性状
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Liquid
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浓度
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1mg/ml
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储存液
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0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
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发货地
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上海
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背景资料
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This e encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and eniotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target es involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target e transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this e. [provided by RefSeq, Jul 2008]
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