商品属性：
|
产品名称
|
COP1抗体
|
|
英文名称
|
COP1
|
|
产品规格
|
50ul 100ul 200ul
|
|
产品货号
|
GOY-01K0221
|
|
产品分类
|
抗体 / 一抗
|
|
交叉反应
|
Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep
|
保存条件
|
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
|
|
标记
|
Unconjugated
|
抗体来源
|
Rabbit
|
|
抗体类型
|
Polyclonal
|
研究领域
|
信号转导 表观遗传学 泛素
|
|
蛋白细胞定位
|
细胞核,细胞浆
|
纯化方法
|
affinity purified by Protein A
|
|
性状
|
Liquid
|
浓度
|
1mg/ml
|
|
储存液
|
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
|
发货地
|
上海
|
|
背景资料
|
COP1 is an E3 ubiquitin ligase protein that mediates ubiquitination and degradation of target proteins such as c-Jun and p53. It is a component of the DCX DET1-COP1 ubiquitin ligase complex which consists of RBX1, DET1, DDB1, CUL4A and COP1. Localizing to the cytoplasm and to the nucleus, COP1 is primarily expressed in testis, placenta, heart and skeletal muscle. COP1 is a potent inhibitor of p53-dependent transcription and apoptosis but, when phosphorylated by Atm (ataxia telangiectasia mutated) in response to DNA damage, the COP1-p53 complex is disrupted and p53 is allowed to exert its pro-apoptotic properties. In ovarian and breast cancers, COP1 is overexpressed, suggesting a role for COP1 in tumoriesis.
|
公司正在出售的产品：
125mL Triton Lysis Buffer with Glycerol,2X Triton Lysis Buffer with Glycerol,2X 常温保存ONPG发酵管进口、国产ONPG发酵管20支BR
0.1mg 山羊抗小鼠IgG，荧光素555标记 Goat Anti-Rabbit IgG ,IF555 Conjugate 4℃保存 7.8-500 pg/mL. 人白介素15(IL-15)ELISA试剂盒
2 ug pIL253 pIL253 低温运输，-20℃保存 78-5000 pg/mL ELISA Kit for Human Angiopoietin-related protein 4
Fortum 3mg/支*5 0.625-40 ng/mL ELISA Kit for Human Cyclin-dependent kinase 5
100g RNSDS (十二烷基) 常温 0.312-20 ng/mL 人抵抗素(RETN)ELISA试剂盒
2.5g 木聚糖 Xylan 室温干燥保存
2 ug pSos MAFB pSos MAFB 低温运输，-20℃保存 78-5000 pg/mL ELISA Kit for Human Adenomatous polyposis coli protein
MKTTn肉汤（ISO） MKTTn Broth 250g牛胆酸进口、国产Cholic acid25克BR，98%
2 ug pLVX-ZsGreen1-N1 pLVX-ZsGreen1-N1 低温运输，-20℃保存 0.156-10 ng/mL ELISA Kit for Human Serine/arginine-rich splicing factor 2
麦芽糖发酵管 20支 0.312-20 ng/mL 人臂板蛋白-3G(SEMA-3G)ELISA试剂盒
半固体琼脂 Semi-solid agar 250g 78-5000 pg/mL 人神经营养因子3(NT-3)ELISA试剂盒
COP1抗体1瓶 L Wnt-3A细胞株 L Wnt-3A 低温运输和保存苯脱氨 Phenylalanine Deaminase Medium 1ml*20250U 天 L-Asparaginase 4℃保存100mL Sodium Pyrophosphate Solution（焦钠缓冲液），200mM Sodium Pyrophosphate Solution，200mM 常温保存50mL 动物细胞裂解液B（变性） Animal Cell Lysis Solution 4℃保存
大鼠 REG4 人细胞裂解液 (阳性对照) (变性)
大鼠 CD111 / Nectin-1 / PVRL1 人细胞裂解液 (阳性对照) (变性)
大鼠 ALCAM / CD166 人细胞裂解液 (阳性对照) (变性)
大鼠 XEDAR / EDA2R 人细胞裂解液 (阳性对照) (变性)
大鼠 IL2RG / CD132 人细胞裂解液 (阳性对照) (变性)
大鼠 IL2RG / CD132 人细胞裂解液 (阳性对照) (变性)
大鼠 EphA4 人细胞裂解液 (阳性对照) (变性)
小鼠 Cadherin-6 / CDH6 人细胞裂解液 (阳性对照) (变性)
甲型流感 H10N9 (A/duck/HongKong/562/1979) 血凝素 (Hemagglutinin / HA) 人细胞裂解液 (阳性对照) (变性)
人 AGER / RAGE 人细胞裂解液 (阳性对照) (变性)